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Creatine monohydrate refers to creatine that has been bound with a molecule of water. It is frequently used by athletes and body builders to enhance athletic ability. Creatine is naturally created by the body and is also ingested in meats, but supplements of creating monohydrate increase the amount found in the body. This affects the skeletal muscles, in particular, as over 90% of the creatine in the body can be found in these muscles. This is primarily because creatine is instrumental in energy availability, and the skeletal muscles - particularly in a serious athlete - use a lot of energy. Creatine supplements have long been shown to increase creatine in the muscles, making it easier to get the most out of a workout and build lean skeletal muscle.

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