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The synergism between the two (BCAA & Glutamine) exists because, not only do they both induce many of the same anabolic and anti-catabolic effects, but under stressful conditions BCAA's can directly contribute to glutamine stores by serving as donors to the formation of glutamine. Amongst athletes a relatively low dose combination of BCAA (3 grams) and glutamine (5 grams) supplemented during training was found to promote a 2-pound greater gain in muscle mass and greater gains in strength versus ingesting whey protein alone.

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