Creatine is a supplement that helps build lean skeletal muscle and provides energy for contracting the muscles. Nitric oxide is a natural vasodilator, opening the blood vessels for optimal blood flow. For body builders and serious athletes, nitric oxide -- also abbreviated NO or NO2 -- is a useful boost to muscle pump. Blood flow to the muscles is important for delivering oxygen and nutrients. When exercising, nitric oxide is released during muscle contraction, allowing blood to rush through the veins and creating what is known as pump. Adding NO to your creatine supplement creates a continuous pump and has a synergistic effect with the creatine, increasing strength, endurance and muscle growth.